The purpose of health promotion is not only to enhance health but also to improve the quality of life (QOL). Metabolic syndrome (MetS) can be alleviated through a change in health habits as it is closely linked to lifestyle. However, when left untreated, MetS will limit the daily activities of the affected individual and reduce his/her QOL. This study aims to analyze the structural equation modeling of relationships between QOL, eating behavior change, and MetS. We recruited 87 individuals (35 males, 52 females; mean age 60.8 years) who attended a program conducted by Tenshi Health and Nutrition Clinic. The participants received educational intervention for 3 months; the intervention was based on the transtheoretical model of behavior change. The intervention resulted in improved QOL scores, along with an improvement in the stage of eating behavior change, increased health-related indicator levels, decreased dietary energy intake, and improved MetS index level. After intervention, improvement in QOL was correlated with the scores of social support (SS) for eating behavior change (eating behavior SS) as well as with the changing rates of abdominal circumference and diastolic blood pressure. These results indicated a structural equation modeling that QOL improvement was related to changes in health practice index and abdominal circumference. Both changes resulted from improvement in the stage of eating behavior facilitated by improved eating behavior SS. Further research is required to elucidate the structural modeling involved in the enhancement of QOL associated with the alleviation of MetS.